Can monitor multiple time points to
follow kinetics.
One-step, no wash assay.
Adaptable for High Throughput format
Highly Sensitive
Applications - Fluorescence
(Plate Reader) or Absorbance
Assay Principle
Eosinophil peroxidase (EPO) is the most
abundant enzyme found in eosinophils. It is
the major cytotoxic agent released by
activated eosinophils and uses hydrogen
peroxide to generate reactive oxidants from
halides and pseudo halide thiocyanate [1,2].
Eosinophils peroxidase has been shown to
have antimycobacterial activity [3], however
it is also implicated in tissue damage that
occurs in asthma and other diseases [4,5].
Currently, the function of eosinophil
involvement in the immune response is being
redefined. Once considered a cell involved
in host protection of parasitic infection,
eosinophils multiple functions as leukocytes
involved in the initiation and propagation
of diverse inflammatory responses are being
investigated. Eosinophils are further
involved as modulators of innate and
adaptive immunity [6].
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Marienbongard 20
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